On the global well-posedness for the Boussinesq system with horizontal dissipation

In this paper, we investigate the Cauchy problem for the tridimensional Boussinesq equations with horizontal dissipation. Under the assumption that the initial data is an axisymmetric without swirl, we prove the global well-posedness for this system. In the absence of vertical dissipation, there is no smoothing effect on the vertical derivatives. To make up this shortcoming, we first establish a magic relationship between $\frac{u^{r}}{r}$ and $\frac{\omega_\theta}{r}$ by taking full advantage of the structure of the axisymmetric fluid without swirl and some tricks in harmonic analysis. This together with the structure of the coupling of \eqref{eq1.1} entails the desired regularity.Comment: 32page

In vivo nematicidal potential of camel milk on Heligmosomoides polygyrus gastro-intestinal nematode of rodents

Following our previous fi ndings on the in vitro anthelmintic effect of camel milk on Haemonchus contortus, the current study aimed at investigating its in vivo effect. Investigations were carried out using mice infected with Heligmosomoides polygyrus which is a parasite commonly used to test the effi cacy of anthelmintics. Thirty six Swiss white mice of both sexes aged 5 – 6 weeks old, and weighing between 20 and 25 g were orally infected with 0.5 ml dose of 100, 1-week-old H. polygyrus infective larvae (L3 ). After the pre-patent period, infected animals were randomly divided into 6 groups of 6 animals each. The nematicidal effi cacy of camel milk was monitored through faecal egg count reduction (FECR) and total worm count reduction (TWCR). Four doses (8.25; 16.5; 33.0; 66.0 ml/kg body weight (bw)) for fresh camel milk and 22 mg/kg bw for albendazole were studied using a bioassay. Albendazole and 4 % dimethylsulfoxide were included in the protocol as reference drug and placebo, respectively. For all tested doses except 8.25 ml/kg bw, camel milk was effective in vivo against H. polygyrus reducing both faecal egg count and worm count (p < 0.05). The dose 66 ml/kg bw showed the highest nematicidal activity causing a 76.75 % FECR and a 69.62 % TWCR 7 day after initiating the treatment. These results support the possible use of camel milk in the control of gastro-intestinal helminthiasis

Golabi-Ito-Hall syndrome results from a missense mutation in the WW domain of the PQBP1 gene

Background: Golabi, Ito, and Hall reported a family with X linked mental retardation (XLMR), microcephaly, postnatal growth deficiency, and other anomalies, including atrial septal defect, in 1984.Methods: This family was restudied as part of our ongoing study of XLMR, but significant linkage to X chromosome markers could not be found. Extreme short stature and microcephaly as well as other new clinical findings were observed. Mutations in the polyglutamine tract binding protein 1 gene (PQBP1) have recently been reported in four XLMR disorders (Renpenning, Hamel cerebro-palato-cardiac, Sutherland-Haan, and Porteous syndromes) as well as in several other families. The clinical similarity of our family to these patients with mutations in PQBP1, particularly the presence of microcephaly, short stature, and atrial septal defect, prompted examination of this gene.Results: A missense mutation in PQBP1 was identified which changed the conserved tyrosine residue in the WW domain at position 65 to a cysteine (p.Y65C).Conclusions: This is the first missense mutation identified in PQBP1 and the first mutation in the WW domain of the gene. The WW domain has been shown to play an important role in the regulation of transcription by interacting with the PPxY motif found in transcription factors. The p.Y65C mutation may affect the proper functioning of the PQBP1 protein as a transcriptional co-activator

The regularized 3D Boussinesq equations with fractional Laplacian and no diffusion

In this paper, we study the 3D regularized Boussinesq equations. The velocity equation is regularized \`a la Leray through a smoothing kernel of order $\alpha$ in the nonlinear term and a $\beta$-fractional Laplacian; we consider the critical case $\alpha+\beta=\frac{5}{4}$ and we assume $\frac 12 <\beta<\frac 54$. The temperature equation is a pure transport equation, where the transport velocity is regularized through the same smoothing kernel of order $\alpha$. We prove global well posedness when the initial velocity is in $H^r$ and the initial temperature is in $H^{r-\beta}$ for $r>\max(2\beta,\beta+1)$. This regularity is enough to prove uniqueness of solutions. We also prove a continuous dependence of the solutions on the initial conditions.Comment: 28 pages; final version accepted for publication in Journal of Differential Equation

How Pakistan\u27s media spreads the message about reproductive and sexual health

Abstract, issue, and pagination are not provided by the author/publishe

POEMS Syndrome Presentation with an Abscess within the Plasmacytoma—A Rare Case Report

POEMS Syndrome is a rare cause of demyelinating and axonal mixed neuropathy. Plasmacytomas are usually seen in POEMS syndrome and can be osseous or extramedullary. Plasmacytomas presenting as an abscess has not been noted earlier. Our patient presented with localized hyperpigmented patch on the back and later developed progressive weakness in upper and lower limbs. Initially serum and urine protein electrophoresis were normal. The patient was thought to have Chronic Inflammatory Demyelinating Polyneuropathy and was treated accordingly without any improvement. Repeat serum protein electrophoresis showed monoclonal gammopathy. MRI of the back revealed an abscess in the paravertebral soft tissues reaching up to the skin. Needle biopsy was consistent with plasmacytoma. Later, he developed a purulent fungating lesion in the lower midback. Antibiotics were started and local resection was done followed by radiation. Pathology of the resected mass showed plasmacytoma extensively involving subcutaneous soft tissue and bone. The patient improved with the treatment. Cystic plasmacytomas and abscess within the plasmacytoma has not been reported earlier. Whether abscess formation is part of the disease spectrum due to infiltration of overlying tissue or is secondary to localized immunosuppression is unknown. Local treatment of a single plasmacytoma is useful in ameliorating systemic symptoms

Performance management practices in humanitarian organisations

Purpose – We examine how design and implementation practices for supply chain performance management that have proven successful in commercial organisations apply to Humanitarian Organisations (HOs) to guide the process of designing and implementing performance management in humanitarian organisations. Design/methodology/approach – We identify from the literature 10 successful practices regarding the design and implementation of supply chain performance management in commercial businesses. We apply these, using action research over a four-year period, at Médecins sans Frontières (MSF) Belgium and draw conclusions from this. Findings – We find that tools and techniques, such as workshops and technical sheets, are essential in designing and implementing supply chain performance measurement projects at HOs. Furthermore, making a link to an IT project is crucial when implementing performance measurement systems at HOs. Overall, our case study shows that performance management practices used in business can be applied and are relevant for humanitarian supply chains. Originality/value – Previous research has argued that there are few empirical studies in the domain of performance management at humanitarian organisations. To the best of our knowledge, this paper is the first to provide a longitudinal understanding of the design and implementation of supply chain performance measurement at HOs